Boro will be without captain George Friend for the remainder of the season, Tony Pulis has confirmed.
Boro head to the University of Bolton Stadium on Tuesday evening.
Boro were cruising in the game until a 2nd half red card to defender Daniel Ayala tilted the match in favour of Preston North End.
Despite taking a 6th-minute lead courtesy an Ashley Fletcher strike, two late goals from Brentford means Boro are now 12 points adrift of the top two teams in the Championship.
Middlesbrough, who currently sit 5th in the Championship, need a win to maintain pressure on sides above them in the table.
A relatively new Middlesbrough player getting stick from his own fans – hardly breaking news is it?
The Middlesbrough manager is confident that Hugill has what it takes to spearhead the team’s push for promotion to the Premier League.
Middlesbrough FC are coming into this game on the back of a lackluster performance at the weekend, one in which an own goal by Jayden Bogle spared their blushes.